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31) By far the shakiest part of the calculation is the average mutation rate.

32) The more elaborate the ornament, the more likely that a random mutation will make the ornament less elaborate, not more.

33) Alternatively, this mutation might lead to production of a protein that is only partly functional and causes a milder disease.

34) The concept of an advantageous mutation spurring evolution is the standard model with which evolutionists still work.

35) For the last 20 years researchers have been able to calculate genome sizes and mutation rates.

36) If the mutation creates or destroys a restriction site then this can be simply examined in the products of the reaction.

37) Immunocytochemistry can then be used as a marker of p53 mutation, although DNA sequencing remains the gold standard.

38) If this shows a lethal mutation it is classified as a presumed mammalian mutagen.

39) The mutation leads to change in the transcript level equilibrium.

40) The mutation rate is bound to place an upper limit on the rate at which evolution can proceed.

41) The use of immunohistochemical staining as a marker of point mutation has been critically reviewed by Wyndord-Thomas.

42) Direct DNA sequencing of the relevant amplification products in both patients was used to characterize each mutation.

43) The aim is to discover how far mutation has depressed survival and fertility below their optimal values.

44) It's one of the most rewarding attributes they possess - discovering and articulating the weird mutation in the human race.

45) One of the original bugs had undergone a mutation that caused it to excrete acetate[sentencedict.com], an organic chemical.

46) Over time, in a certain percentage of cells, that mutation caused further errors.

47) But in the 1980s, scientists found that a genetic mutation was responsible.

48) Was it feasible, was it remotely possible, that the mutation had some sort of driving force?

49) A clear example of a mutation altering development is the inherited genetic defect, sickle cell anaemia.

50) Perhaps gene therapy could prevent the mutation of the prion gene that causes hereditary brain disease.

51) Gerda could be searching for Kay to give him the therapy injection that will save him from the mutation disease.

52) Yet despite the handicap ensuing from the mutation, and contrary to observations in human pathology, the strain appears to be unaffected.

53) His only thought was to get away, away from those madmen, away from the mutation, away from the cathedral.

54) Loss of tumour suppressor function requires inactivation of both alleles, usually by chromosomal deletion or point mutation, or both.

55) Once a mutation that causes an abnormality is observed, it becomes possible to try and identify and isolate the gene.

56) Shaken free from its sand, a casting looked like nothing so much as a grotesque mutation of the final part.

57) Two out of 160 G418-resistant D3 clones were found to have the targeted mutation and clone 515 gave rise to germ-line chimaeras.

58) In splurge-weed, the new mutation can arise in any cell,(http://sentencedict.com/mutation.html) in any branch of the plant.

59) Near neighbours in genetic space are animals that differ from one another by only a single mutation.

60) When a segregation distorter arises by mutation, it will spread inexorably through the population at the expense of its allele.