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151. This is a very significant advantage as discussions about different weightings are not held up while new calculations are made.

152. The only significant association was an increased risk of leukaemia and non-Hodgkin's lymphoma associated with first pregnancy.

153. The ultimate aim of the counselling process is to achieve significant improvement in the social and interpersonal relationships of the counsellee.

154. This was a significant achievement in the highly competitive situation to which I have referred.

155. Already in the background there were the significant achievements of the newly developed science of geology.

156. First and most significant is the possibility of some kind of nuclear war or accident that would destroy the human race.

157. When considering bids, preference will be given to bids involving significant employee participation.

158. Land could be sold off or developed, causing significant harm to present areas of natural beauty and important wildlife habitats.

159. The geographical context is not all that matters, but it is the most significant.

160. A modest journal article might have produced for the author a significant learning experience.

161. However, the rewards of spending a significant amount of time with your offspring brings great spiritual benefit.

162. It was a significant archaeological enterprise advancing into unknown territory in the small towns of Roman Britain.

163. This afternoon his doctors performed angioplasty after a diagnostic test showed significant narrowing of one coronary artery at two different sites.

164. It is therefore a significant achievement and bound to be considerable commercial value.

165. Like forest manipulation, afforestation also modifies the environment and must thus be regarded as a significant agent of environmental change.

166. The presence of significant amounts of haemoglobin F has a protective effect against sickling and such individuals express relatively mild disease.

167. There is, it is heartening to note, quite widespread acceptance that language is significant in all subject areas.

168. Other new appointments made in response to the changing balance in international relations between economic and political considerations were less significant.

169. One very significant change from Morgan we can attribute to Marx.

170. Significant moments in history do not happen without some kind of advance warning.

171. Assumptions about the rate of payment by debtors may have a significant bearing on the expected profitability of the project.

172. In accordance with Wyatt etal we found a significant association between the extent of gastric metaplasia and microscopic signs of duodenitis.

173. Every man who knows how to read has it in his power to magnify himself, to multiply the ways in which he exists, to make his life full,[http://sentencedict.com/significant.html] significant and interesting. Aldous Huxley 

174. There were no significant differences in the serum lactate, pyruvate, or alkaline phosphatase concentrations between the treatment groups.

175. Pumps in the backpack circulated water round the pipes without loosing significant amounts.

176. Women worried about the cosmetic effects of insect bites on the face make up a significant proportion of those seeking medical assistance.

177. This specifically educational definition has of course continued, but its adoption by artists marks a significant shift.

178. The economic case for substantial immigration is thin, and there are significant ecological and other arguments against it.

179. There are, however, significant differences between the political affiliations of 585 and 587.

180. Rivers, through his marriage to the heiress of the Scales barony, held a significant block of land in Norfolk.