Synonym: conundrum, enigma, issue, mystery, perplexity, puzzle, question. Antonym: solution. Similar words: probably, robot, oblivious, obligation, lemon, element, dilemma, implement. Meaning: ['prɑbləm /'prɒ-] 
n. 1. a state of difficulty that needs to be resolved 2. a source of difficulty 3. a question raised for consideration or solution.
n. 1. a state of difficulty that needs to be resolved 2. a source of difficulty 3. a question raised for consideration or solution. 
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61 Those facts were influential in solving the problem.
62 Sleep disorders are a serious psychological problem .
63 The problem has worsened considerably in recent months.
64 Have you resolved the problem of transport yet?
65 There are no definitive answers/solutions to this problem.
66 She is worrying the problem out.
67 It was difficult to explain the problem to beginners.
68 The solution to the problem required many hours.
69 This problem is outside the domain of medical science.
70 He was well aware of the problem.
71 Poverty is a more pressing problem than pollution.
72 The problem was discovered during routine monitoring.
73 She refused to accept that there was a problem.
74 I don't know how to tackle this problem.
75 Public transport is a big problem in this locality.
76 The engineer is capable of handling the problem.
77 Crime is an increasingly serious problem in Russian society.
78 The problem is not confined to Germany.
79 Do you know how to deal with this problem?
80 We have gained sufficient experience to tackle this problem.
81 The problem and the answer are very simple.
82 He is awake to the serious problem.
83 She dealt with the problem with consummate skill.
84 The recession has exacerbated this problem.
85 She got no credit for solving the problem.
86 The problem only exists in your head(sentencedict.com), Jane.
87 It's always a problem deciphering his handwriting.
88 The problem is purely physical, not mental.
89 This problem calls for swift/prompt action from the government.
90 We now have a clearer conception of the problem.
More similar words: probably, robot, oblivious, obligation, lemon, element, dilemma, implement, settlement, elementary, finite element, implementation, pro, able, table, cable, bless, blend, Bible, bubble, enable, unable, marble, double, foible, prompt, be able to, visible, voluble, stumble.