Synonym: give up, desire, hope. Similar words: pair, impair, repair, a pair of, thomas paine, impairment, despite, desperate. Meaning: [dɪ'speə] 
n. 1. a state in which everything seems wrong and will turn out badly 2. the feeling that everything is wrong and nothing will turn out well. v. abandon hope; give up hope; lose heart.
n. 1. a state in which everything seems wrong and will turn out badly 2. the feeling that everything is wrong and nothing will turn out well. v. abandon hope; give up hope; lose heart. 
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(151) She felt she had run the gamut of human emotions from joy to despair in one day.
(152) She wailed with despair.
(153) Despair choked her words.
(154) Just thinking about the future plunged her into a pit of despair .
(155) Many of Munch's paintings express a deep feeling of despair.
(156) I tried to drag myself out of the morass of despair.
(157) The night before the test I was overcome by fear and despair.
(158) Such despair had swept over her as she had never before known.
(159) Her husband's violent and abusive behaviour drove her to the verge of despair.
(160) The thought drove him to despair and drink.
(161) There is prodigious strength in sorrow and despair. Charles Dickens 
(162) My poor master was in the depths of despair.
(163) Despair as despair at lack of salvation,[http://sentencedict.com/despair.html] wrote Harsnet.
(164) I could understand her despair at her homelessness.
(165) I believe in passing on hope, not despair.
(166) Sometimes my self-pity billowed into bleak, inconsolable despair.
(167) My mind went blank with grief and despair.
(168) Perhaps the chaps at Life shouldn't despair.
(169) Hope is antithetic to despair.
(170) The heavy boughs and dark leaves of the copper beech that spread over the drive perfectly suited her mood of despair.
(171) The artist has taken the white-veiled bride, conventional symbol of hope and purity, and installed her into settings of despair.
(172) Earlier in the day, I had been close to despair.
(173) It has, none the less, saved millions of families from hunger, homelessness, physical assault, and total despair.
(174) Patience: A minor form of despair disguised as a virtue. Ambrose Bierce
(175) Strong words which no one would contradict with confidence, even if despair was regarded as an emotion which should never be admitted.
(176) Do not be lost in the deep darkness of despair and hopelessness.
(177) If calligraphy is not a skill you possess or think you could learn, do not despair for there are some alternatives.
(178) At the end of two weeks she was tired, frustrated, and close to despair.
(179) This is not a matter of poor teaching, for such students can be the despair of conscientious teachers.
(180) A cry of despair was turned into a Declaration for Democracy.