Synonym: ache, discomfort, distress, hurt, irritation, pang, soreness, suffering. Antonym: pleasure, relieve. Similar words: painter, paintwork, maintain, pair, impair, repair, a pair of, campaign. Meaning: [peɪn]
n. 1. a symptom of some physical hurt or disorder 2. emotional distress; a fundamental feeling that people try to avoid 3. a somatic sensation of acute discomfort 4. a bothersome annoying person 5. something or someone that causes trouble; a source of unhappiness. v. 1. cause bodily suffering to and make sick or indisposed 2. cause emotional anguish or make miserable.
6. Every pleasure has a pain.
12. No man can be brave who considers pain the greatest evil of life; or temperate,[sentencedict.com] who regards pleasure as the highest good. 

15. No pain, no gain.
16. A certain amount of care or pain or trouble is necessary for every man at all times.A ship without a ballast is unstable and will not go straight. 

18. No pleasure without pain.
19. The pain was almost too great to endure.
20. The constant pain made her life intolerable.
21. The wounded soldier lashed around in great pain.
22. Without pain, without sacrifice, we would have nothing.
23. The patient's face twisted up with pain.
24. The tablets brought temporary respite from the excruciating pain.
25. The pain in her jaw had come back.
26. The spider's bite can cause pain and swelling.
27. He moaned with pain before losing consciousness.
28. When I bend my arm, the pain is excruciating.
29. She was in constant physical pain.
30. The booklet contains information on pain relief during labour.