Synonym: give up, desire, hope. Similar words: pair, impair, repair, a pair of, thomas paine, impairment, despite, desperate. Meaning: [dɪ'speə] 
n. 1. a state in which everything seems wrong and will turn out badly 2. the feeling that everything is wrong and nothing will turn out well. v. abandon hope; give up hope; lose heart.
n. 1. a state in which everything seems wrong and will turn out badly 2. the feeling that everything is wrong and nothing will turn out well. v. abandon hope; give up hope; lose heart. 
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(121) He fell into despair.
(122) I was in the depths of despair when the baby was sick.
(123) I looked in despair at the long line in front of the ticket office.
(124) The noise from the neighbours used to drive him to despair .
(125) To the despair of the workers, the company announced the closure of the factory.
(126) He was pitched into despair by what happened to him in his final year at college.sentencedict.com
(127) Don't despair! We'll think of a way out of this.
(128) A feeling of despair descended as we realized that we were completely lost.
(129) Although the men fought doggedly on, a sense of hopeless despair engulfed them.
(130) He turned to her in despair and said, 'You're my last hope.'
(131) The rejection plunged her into the dark depths of despair.
(132) We've despair of him; he can't keep a job for more than six months.
(133) His poems reveal the duality of his nature, the joy and hope, the fear and despair.
(134) If you are in the depths of despair, you are extremely unhappy.
(135) If we can't bring our problems under control, feelings of powerlessness and despair often ensue.
(136) It was at that stage in her life when she plumbed the depths of despair.
(137) When his friend was killed, he plumbed the depths of despair.
(138) To her teacher's despair, Nicole never does the work that she's told to do.
(139) They frequently plumb the depths of loneliness, humiliation and despair.
(140) He fought against despair.
(141) He returned to New York under a cloud of gloom and despair.
(142) He's the despair of his parents because he shows no interest in getting a job.
(143) This poem runs the gamut of emotions from despair to joy.
(144) When he became ill he sank to the depths of despair.
(145) He moaned in despair.
(146) Despair seems to have set in among the England team.
(147) After his wife's death, he seemed to give himself over to despair.
(148) He sighed with despair at the thought of all the opportunities he had missed.
(149) His mother flung up her hands in despair when the boy failed yet another examination.
(150) Don't let yourself despair; this will only make matters worse.