Synonym: give up, desire, hope. Similar words: pair, impair, repair, a pair of, thomas paine, impairment, despite, desperate. Meaning: [dɪ'speə] 
n. 1. a state in which everything seems wrong and will turn out badly 2. the feeling that everything is wrong and nothing will turn out well. v. abandon hope; give up hope; lose heart.
n. 1. a state in which everything seems wrong and will turn out badly 2. the feeling that everything is wrong and nothing will turn out well. v. abandon hope; give up hope; lose heart. 
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(241) He gazed at the confusion around him and was overwhelmed by a feeling of despair.
(242) There was a mood of despair about the quality of urban and industrial life.
(243) Mr Yeltsin's appeal looks like a gesture of despair after his failure to influence the central government.
(244) By the time we reached Totnes, in Devon, we had abandoned ourselves to our despair.
(245) The days of numbing despair had been reduced to quick flashes of temper that Duvall always managed to calm.
(246) He remembered that ghastly hunt across the fields at Woodstock and bit his lip at the despair he felt.
(247) Left all alone in her room, she was in despair.http://Sentencedict.com
(248) 'Jane Eyre' is Bronte's classic novel of courage in the face of despair.
(249) Small things would make her happy; one harsh word would send her into the depths of despair.
(250) By three to four minutes their whole bodies slumped in despair.
(251) It's despair that anyone can even contemplate the idea of dropping a bomb or ordering that it should be dropped.