Antonym: insignificant. Similar words: significantly, significance, sign in, specifically, esterification, identification, sign on, signal. Meaning: [sɪg'nɪfɪkənt] 
adj. 1. important in effect or meaning 2. fairly large 3. too closely correlated to be attributed to chance and therefore indicating a systematic relation 4. rich in significance or implication.
adj. 1. important in effect or meaning 2. fairly large 3. too closely correlated to be attributed to chance and therefore indicating a systematic relation 4. rich in significance or implication. 
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91. Your success today may be significant for your whole future.
92. There has been significant progress in in understanding the HIV infection.
93. This treatment represents a significant advance in the field of cancer research.
94. There have been significant computer developments during the last decade.
95. Susan nodded sagely as if what I had said was profoundly significant.
96. The result is highly significant for the future of the province.
97. You may remember the way each scene ended with someone looking pensive or significant.
98. If all the coronary arteries are free of significant obstructions, all parts of the heart will receive equal amounts of oxygen.
99. I think it was significant that he never knew his own father.
100. The Hubble Telescope has allowed astronomers to make significant discoveries about our galaxy.
101. Air pollution has become one of the most significant health problems of our time.
102. The drug has had no significant effect on stopping the spread of the disease.
103. It is significant that girls generally do better in examinations than boys.
104. There is a significant difference between the number of home births now and ten years ago.
105. The laxity of export control authorities has made a significant contribution to the problem.
106. 7th May[sentencedict.com], 1999 was a very significant date in my life.
107. In recent months, the rebels have scored some significant victories.
108. There have been significant changes in the power structure of the company.
108. Sentencedict.com try its best to gather and build good sentences.
109. The learner's attention needs to be directed to the significant features.
110. The offer of talks with Moscow marks a significant change from the previous western position.
111. Lotus make luxury cars for a small but significant niche market.
112. The treatment of diabetes reached a significant milestone in the 1970s.
113. The discovery marks a significant technological advance.
114. The symbolic act could not have been more significant.
115. Significant questions will go unasked.
116. Such a treatment would still be a significant advance.
117. Belfast is attracting significant new private investment.
118. Conversely, there was no significant association with portal hypertension.
119. Murray's accomplishments in this book are significant.
120. Are most significant social changes directly attributable to violence?
More similar words: significantly, significance, sign in, specifically, esterification, identification, sign on, signal, design, resign, assign, terrific, specific, designs, designer, design for, scientific, artificial, signature, assignment, efficacy, uniform, even if, cognitive, magnitude, recognition, sigh, office, campaign, foreigner.