Synonym: give up, desire, hope. Similar words: pair, impair, repair, a pair of, thomas paine, impairment, despite, desperate. Meaning: [dɪ'speə] 
n. 1. a state in which everything seems wrong and will turn out badly 2. the feeling that everything is wrong and nothing will turn out well. v. abandon hope; give up hope; lose heart.
n. 1. a state in which everything seems wrong and will turn out badly 2. the feeling that everything is wrong and nothing will turn out well. v. abandon hope; give up hope; lose heart. 
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(31) One harsh word would send her into the depths of despair.
(32) His mind seesawed between hope and despair all through those weeks.
(33) When his wife left him, Matt plumbed the very depths of despair.
(34) Our destiny offers not the cup of despair, but the chalice of opportunity. So let us seize it, not in fear, but in gladness.
(35) Our destiny offers not the cup of despair, but the chalice of opportunity. So let us seize it, not in fear, but in gladness.——R.M.
(36) Nothing in life is despair, a series of disaster will be can't withstand the sunshine nightmare, to be bumpy.Life is the dojo,[www.Sentencedict.com] alive is a kind of practice.
(37) I take this moment to tell you today that I'm so grateful for the love that you give me.Your smiling face is like the sunlight which brightens my world.The comfort and encouragement you give to me help me through all the despair. Words can not express how much I feel for you.You're a wonderful wife who deserve all my love.Have a happy birthday!
(38) Eventually, driven to despair, he threw himself under a train.
(39) The novel tells the story of a teenager driven to despair by the hypocrisy of the adult world.
(40) When I learn to despair, you tell me, don't have to pretend!
(41) Through the total fading away and extinction of craving, decay and death, sorrow, lamentation, suffering, grief, and despair are extinguished.
(42) Never despair of success.
(43) She finished what she had to say with a gesture of despair.
(44) I like a lonely puppet, lost and I follow like a shadow another puppet, never show will not move, was abandoned in the corner of dusty, alone in despair, in a desperate sad, then continue to missing you.
(45) I promise you, I'm always there, when your heart is filled with sorrow and despair.
(46) If not for you, I must be shivering in the despair and fear, groaning painfully. But for you, every day I will dream the most beautiful apart. Becoz u use your whole life to love me, and I feel free. My life seems to leave me like the sand flowing. I can hear that, but I can still smile only as long as I see you sleeping by my side.
(47) He swings from wild optimism to total despair.
(48) He surrendered to despair and eventually committed suicide.
(49) A feeling of despair enveloped him.
(50) I despair at/over the policies of this government.
(51) I despair of ever finding him again.
(52) Those kids are driving me to despair.
(53) Here and there, husbands sit in wordless despair.
(54) Don't abandon yourself to despair.
(55) Don't let yourself sink into despair.
(56) She let out a cry of despair.
(57) She alternated between hope and despair.
(58) His mood swings between elation and despair.
(59) He communicates his despair to me.
(60) The news plunged us into despair.