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1. Several hormones may stimulate platelet activating factor biosynthesis invitro.

2. These results suggest the involvement of platelet activating factor in the endothelin induced fibrinolytic activation and subsequently developed mucosal haemorrhagic lesion.

3. Therefore the platelet-aggregate ratio would be low in the presence of circulating platelet aggregates.

4. The possibility that intestinal epithelial cells may produce platelet activating factor has been suggested by Kald etal.

5. The content of platelet activating factor in pancreatic tissue was determined using bioassay technique with washed rabbit platelets as described previously.

6. Occasionally, a substantially increased platelet or white cell count may lead to apparent increases in plasma potassium concentration.

7. As knowledge of basic platelet metabolism increases it will be more easy to identify platelet abnormalities and their pathogenesis in diabetes mellitus.

8. This hypothesis deserves further study as platelet activating factor metabolism in the stomach lumen is unknown.

9. These authors have shown that colonic platelet activating factor content was significantly increased irrespective of colonic inflammation.

10. Lyso platelet activating factor and alkyl acyl glycerophosphocholine were not significantly higher in Crohn's disease than in controls.

11. This led to a substantial increase in platelet cholesterol concentration, the bulk of this increase being associated with the platelet membrane.

12. Biological activity of platelet activating factor was measured by platelet aggregation using a Chrono-log Corporation aggregometer.

13. The mechanisms by which platelet sticks to platelet during aggregation are not fully understood.

14. Platelet activating factor also caused a marked decrease in the pancreatic blood flow comparable with that observed after caerulein infusion.

15. Formalin fixes platelet aggregates which would be removed during the centrifugation to produce platelet-rich plasma.

16. Platelet-adhesion studies Early studies of platelet function in diabetes used in vitro tests of platelet adhesion.

17. Other authors found similar findings with regard to circulating platelet aggregates.

18. In addition, improved therapeutic agents with more specific and controlled effects on platelet metabolism may be developed allowing more effective intervention.

19. There are, however, some differences in the action of caerulein and platelet activating factor on the pancreas.

20. According to our finding caerulein infused at supramaximal dose increased the production of platelet activating factor in the pancreatic tissue by about nine-fold.

21. The actin filaments extend into the cytoplasm from this point and form long filaments orientated concentrically around the platelet granules.

22. However, bearing in mind these constraints; what is the current evidence linking diabetic control and platelet function?

23. The above studies have attempted to assess the presence of circulating platelet aggregates.

24. However, this suggestion depends on the assumption that prostacyclin is continually produced by arterial wall to prevent platelet aggregation.

25. Platelets are studied in an artificial environment and the very process of preparing the platelet sample for study may affect their behaviour.

26. About 24 hours before assay the sample was placed in 80% ethanol to extract platelet activating factor from the tissue.

27. For these reasons studies detailing the effects of diabetic control on platelet function must be interpreted with caution.

28. This has led to difficulties in interpretation of the possible sequence of events in the development of enhanced platelet reactivity in diabetics.

29. These findings suggest that lipoprotein abnormalities in the diabetic state may also indirectly affect platelet function by damaging vascular endothelium.

30. Gliclazide is the sulphonylurea that has received most study in terms of possible effects on platelet function.