Synonym: barrier, block, catch, deterrent, hindrance, hitch, impediment, obstruction, snag, stoppage. Antonym: help. Similar words: spectacle, obstreperous, manacle, miracle, stack, substance, substantial, substantially. Meaning: ['ɑbstəkl /'ɒb-] 
n. 1. something immaterial that stands in the way and must be circumvented or surmounted 2. an obstruction that stands in the way (and must be removed or surmounted or circumvented).
n. 1. something immaterial that stands in the way and must be circumvented or surmounted 2. an obstruction that stands in the way (and must be removed or surmounted or circumvented). 
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271. For drug companies, the placebo effect can pose an obstacle to profits--if their medications fail to outperform placebos in clinical trials, they won't get approved by the FDA.
272. "The main obstacle that we tend to encounter in developing refugee camps is digging of latrines," said Nic Iomahaird.
More similar words: spectacle, obstreperous, manacle, miracle, stack, substance, substantial, substantially, a class, observe, observer, abstract, observation, abstinence, intact, attach, tackle, attack, tactic, get across, attach to, uncle, clerk, clear, cycle, cut across, put across, muscle, circle, clear up.