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1 Oncogenes control normal growth cells and their division.

2 Various mutations in both oncogenes and tumour suppressor genes have been implicated heavily in the development of cancer.

3 Invitro, oncogenes cooperate to transform cells and render them tumorigenic.

4 Invitro certain combinations of oncogenes cooperate to transform primary rat cells.

5 Apart from point mutation, another way in which oncogenes can be activated is by over expression.

6 Oncogene: Gene that can cause cancer.

7 Expression of an oncogene in a primary cell can, paradoxically, block proliferation by inducing senescence or apoptosis through pathways that remain to be elucidated.

8 P 53 is an important proto - oncogene involved in the regulation of cell - cycle and apoptosis.

9 Method Exon 17 of RET proto - oncogene from 30 Hirschsprung disease was detected by PCR - SSCP method.

10 Conclusion Mutation of RET proto - oncogene might play an role in the familial Hirschsprung ? ? s disease.

11 The proto - oncogene c - fos mRNA expression was assessed using reverse transcription polymerase chain reaction ( RT - PCR ).

12 Moreover,(www.Sentencedict.com) transformation of tumor cells is involved in oncogene amplification or promoter enhancement.

13 Oncogene products are links in signal chains that stretch from the cell surface to cell nucleus.

14 Elevated levels of GLI1 (glioma-associated oncogene homolog 1) protein in human breast cancer are associated with unfavorable prognosis and progressive stages of disease.

15 Figure 1 . The difference between an oncogene in a virus and in a cell.

16 Plainly in any less desperate case the risk of activating oncogenes would absolutely forbid the use of such a drug.

17 Perhaps the most exciting of future possibilities for genetic intervention in cancer is the direct manipulation of oncogenes or tumour suppressor genes.

18 The EGF receptor is a product of the erb-B oncogene.

19 The researchers showed cancer develops when the function of oncogenes is disturbed and cells grow without control, the Karolinska Institute said.

20 P 16 INK 4 A gene is the first anti - oncogene directly involving in cell cycle regulation.

21 Objective:To investigate the changes in histogenesis and expressions of related oncogene protein in recurrent bone tumor.

22 The stem cell leukemia ( SCL ) gene is a new oncogene related with leukemogenesis.

23 Conclusion:The effect of Weiyankang plus gastrone on precancerosis of gastric cancer may due to repress the abnormal expression of oncogene proteins in gastric mucosa.

24 Objective:To study the effect of Weiyankang plus gastrone on expression of oncogene proteins in gastric mucosa with Precancerosis lesion.

25 Objective To investigate the relationship between the expression of RET proto oncogene and the pathogenesis of Hirschsprung's disease.

26 Proto-oncogene --- A normal gene involved in some aspect of cell division or proliferation that may become activated by mutation or other mechanism to become an oncogene.

27 Pituitary tumor - transforming gene ( PTTG ) is a proto - oncogene separated from pituitary tumor tissue recently.

28 Objective : To confirm the cleavage activity of ribozyme Rz 199 to oncogene K ras messenger RNA.

29 The biological characteristic of carcinomas is determined both by the stromal microenvironment and the oncogene anti - oncogene.

30 A normal gene that has the potential to become an oncogene.