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1 AIM:To evaluate pharmacokinetic characteristics of isosorbide 5 mononitrate(5 ISMN) tablet, 5 ISMN injection, and isosorbide dinitrate(ISDN) injection in Chinese healthy volunteers.

2 METHODS The plasma concentration of 5-isosorbide mononitrate and salicylic acid were determined by GC and HPLC method respectively.

3 The determination of the dissolution of isosorbide 5 mononitrate preparations was carried out with RP HPLC external standard method.

4 Methods intravenous isosorbide mononitrate injection headache in patients with coronary heart disease, 70 cases were randomly divided into treatment group and control group of 35 patients.

5 Isosorbide mononitrate is an active metabolite of isosorbide dinitrate and exerts qualitatively similar effects.

6 Objective To establish a method for detection of bacterial endotoxin in Isosorbide Mononitrate Sodium Chloride Injection.

7 Objective To discuss the application of HPMC in Isosorbide mononitrate IM sustained release tablets.

8 Objective:To compare the clinical effects and side reactions of isosorbide mononitrate(ISMN) and nitroglycerin(NTG) in the treatment of chronic congestive heart failure(CHF).

9 Various drug combinations have been tried, most commonly propranolol with isosorbide mononitrate.

10 Conclusion: the method is operated easily, and has high sensitive and specific, and is suitable to test the assay of Isosorbide mononitrate.

11 Objective To prepare osmotic pump controlled release tablets isosorbide mononitrate.

12 And 33 ones in control group were done with Inj. of Isosorbide Mononitrate only.

13 Objective To observe the use of Gastrodia capsule in patients with coronary heart disease isosorbide mononitrate injection due to the impact of headache.

14 To observe the effects of the combination of propranolol with isosorbide - 5 - mononitrate (ISMN) on portal blood flow in cirrhotic patients with Doppler flowmetry.

15 Objective To prepare osmotic pump controlled release tablets of isosorbide mononitrate.

16 Objective:To compare the clinical effects and side reactions of isosorbide mononitrate and nitroglycerin in the treatment of chronic congestive heart failure.

17 Conclusion Bacterial endotoxin test could be used in Isosorbide Mononitrate and Glucose injection.

18 To establish a method using HPLC to determine the assay of Isosorbide 5— mononitrate (ISMN) in its sustained release capsules.

19 Objective To investigate the clinical efficacy of laser oxygen fluid and isosorbide mononitrate in patients with angina pectoris.

20 Objective To evaluate the efficacy of intravenous drip of isosorbide 5 mononitrate(IS 5 MN) in patients with unstable angina pectoris.

21 Objective To evaluate the effect of captopril United 5-Isosorbide Mononitrate the treatment of chronic cardiac insufficiency of the efficacy and safety.