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1. The overlying epidermis revealed hyperkeratosis and acanthosis.

2. palmar/plantar hyperkeratosis (thickening).

3. Increased amount of hyperkeratosis of epidermal cells were observed on tongue coating smear, with dirty background and more white cells.

4. Conclusions Skin changes of arsenism begin from hyperkeratosis,[http://Sentencedict.com] next affected by depigmentation and hyperpigmentation.

5. Hyperkeratosis of the nipple and areola is a rare entity with unique clinical manifestations.

6. Pathological changes of the abdomen showed hyperkeratosis and mild irregular acanthosis, the granular layer was thin and melanophage and perivascular lymphocytic infiltration in upper dermis.

7. Keratosis clinically with mats, nasal hyperkeratosis of cases caused by multiple neurological symptoms.

8. The lesion showed slightly hyperkeratosis, edema of epidermis, dilated capillary vessel with infiltration of mononuclear cells both in superficial and medial layer.

9. The main manifestation was hypopigment, hyperpigment, and palmoplantar Hyperkeratosis. Triad cases happened in 72 patients (7.35%).

10. In the second stage, white spots appear mixed up with the black (leucomelanosis), legs swell, and the palms and soles crack and bleed (hyperkeratosis).

11. Cutaneous horn of the penis are exaggerated hyperkeratosis of skin arising secondary to a reactive lesion in the dermis or epidermis.

12. Proband also had special clinical feature including follicular hyperkeratosis on the elbows and knees, and onychodystrophy of 20 nails as well.

13. Too few proteins lead to night blindness, perifollicular hyperkeratosis, xerophthalmia, keratomolacia, increased morbidity and mortality in young children.

14. Pathological changes of condyloma are characterized as proliferation, especially dysplasia, hyperkeratosis and parakeratosis.

15. Late yaws appears after five years of the initial infection and is characterized by disabling consequences of the nose, bones and palmar/plantar hyperkeratosis.

16. Objective To understand the situation of secondary skin cancer of hyperkeratosis of skin spot caused by coal burning type of arsenic poisoning.

17. The pathogenesis is not clear, including:excessive secretion of sebum, follicle sebaceous gland duct hyperkeratosis, Propionibacterium acnes proliferation and excessive immune reactions ect.

18. The skin biopsy specimen showed the histologic features of epidermolytic hyperkeratosis .

19. Because the case was not associated with ichthyosis or epidermal nevus, we think it best fits into the category of nevoid hyperkeratosis of the nipple and areola.

20. Objective : To explore the clinicopathological, immunohistochemical feature and therapeutic methods of hyperkeratosis lenticularis perstans.

21. Furthermore, infections become more common, as do fibrosis and other skin changes, such as papillomas, cysts, fistulas , and hyperkeratosis.

22. Objective: To explore the clinic and pathological characteristics of Hyperkeratosis of nipple and areola (HNA) and assess the association of HNA and Human papillomavirus (HPV).

23. We report a case of the nevoid form of hyperkeratosis of the nipple and areola with successful treatment by urea ointment.

24. The histopathologic examination revealed dilatation of intracorneal eccrine ducts with mild focal hyperkeratosis and acanthosis.