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1. Probe, Proinsulin Probe, Rat, Biotin.
2. Proinsulin is formed in rough endoplasmic reticulum.
3. The human proinsulin analog(BKRA)gene molecules were linked tandemly with synthetic nucleotide linker coding RRNSM to form a triplet molecule.
4. The cells combined human proinsulin gene has the ability of producing insulin with increase in glucose concentration in vitro.
5. Objective To explore the relationship between specific insulin, proinsulin and sleep snoring.
6. In normal individual, conversion of proinsulin to insulin is mediated by two endoproteases,[sentencedict.com] PC2 and PC3. There are no PC2 and PC3 but furin in hepatoma cells.
7. Objective To determine serum true insulin (TI) and proinsulin (PI) levels in patients with coronary heart disease (CHD), and to explore the relationships of them to other cardiovascular risk factors.
8. The preparation human proinsulin C-peptide of analogue using of PAM resin was also reported.
9. Proinsulin is a major autoantigen in the disease process, but other autoantigens are likely involved.
10. Objective: To compare the difference of proinsulin and insulin resistance with type 2 diabetes mellitus with hypertension and without hypertension.
11. Secreted proinsulin amounted to about 2 mg per liter was found in the culture medium of yeast strain 63 transformed by plasmid YTI-15.
12. Main Outcome Measures: Glucose, insulin, proinsulin, glucagon(http://sentencedict.com), GIP and GLP-1 levels were measured after 50 gr oral glucose.
13. A gene fragment encoding three copies of proinsulin C peptide was synthesized and expressed in E.
14. Optimization of the renaturation conditions for recombinant human proinsulin inclusion bodies expressed in E.
15. Objective Whether proinsulin(PI)and true insulin (TI) are independently related to coronary artery disease (CAD).
16. Results The sequence of CAC coding for Histidine at B10 site of human proinsulin gene was mutated to the sequence of GAC coding for AsparticAcid.
17. The secretion expression vector of fusion gene in E. coli has constructed by fussing the proinsulin gene to the gene of staphylococcal protein A.
18. MBHA resin is relatively inexpensive. The new method is another way for the preparation of human proinsulin C-peptide.
19. Objective To study primarily the safety of transfering recombinant human proinsulin gene plasmid(RHPGP)into diabetic rats induced by streptozotocin.
20. Now transgene treatment for T1DM is still on the stage of experiment. Its basic process includes six steps : ( 1 ) Obtain the human proinsulin gene.
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