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1. Objective: To observe the liver toxicity caused by Rifamycin.

2. Serious side effects, which were mainly caused by rifamycin agents, occurred within 2 hours after administration.

3. As a derivative of rifamycin, rifalazil has a potential effect against Mycobacterium, which provides an alternative for curing the infections caused by multidrug-resistant Mycobacterium tuberculosis.

4. The rifamycin B production was increased by 17.9%using the optimized media. Results indicated that the procedure proposed in this work has a great potential for practical application.

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5. A semisynthetic antibiotic derived from a form of rifamycin that interferes with the synthesis of RNA and is used to treat bacterial and viral diseases.

6. In this paper, artificial neural network(ANN) was used to predict the relationship between the potency of rifamycin B and the fermentation medium minor error.

7. METHODS The title compounds were designed and synthesized from rifamycin S, and the antibacterial activities of these compounds in vitro were tested.

8. Conclusion: This method can be used for sterility test of Rifamycin Sodium for Injection.

9. Uniform design method was employed to optimize the medium for production of rifamycin SV.

10. To evaluate the therapeutic effect and safety of the rifamycin sodium injection (SV) in treatment of patients with pulmonary tuberculosis.

11. Objective To optimize the content and feeding strategy of barbital sodium during the fermentation of rifamycin B in order to improve the yield.

12. The reaction system and operation conditions for the oxidation of rifamycin B to rifamycin O were studied.