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1. Glucokinase (GK) is considered to be the key regulatory enzyme in glucose metabolism, whose activity changing will lead to glucose metabolic disturbance and diabetes.

2. Pyridin-2 -yl-amino-1, 2, 4 -thiadiazole derivatives as glucokinase activators for the treatment of diabetes mellitus.

3. Objective To evaluate the role of glucokinase(GCK) gene in the pathogenesis of gestational diabetes mellitus(GDM) in Chinese.

4. Objective To investigate the variation of glucokinase(GCK) allele frequency in aged patients with type 2 diabetes mellitus(DM2) and to provide a method for early detection of diabetes mellitus(DM).

5. Objective To explore the associations between glucokinase(GCK) gene, cytotoxic T cell antigen-4(CTLA-4) gene and gestational diabetes mellitus(GDM).

6. Objective: To evaluate the relationship between glucokinase(GCK)gene and non-insulin-dependent diabetes mellitus(NIDDM) in Chinese.

7. Expression of the exogenous genes was confirmed by assay of ? ? - galactosidase and glucokinase activity.

8. An experimental diabetes model was produced by intraperitoneal injection of alloxan. Blood glucose, liver glucokinase and liver glycogen contents were measured.

9. This type of MODY is picked up on routine testing and it is important to identify it when a person is pregnant, although complications associated with glucokinase in pregnancy are rare.

10. The research shows that the mutated IGRP gene blocks the action of a sensor called glucokinase.

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11. Recently, people have realized that there is a good extensive perspective in diabetes research by means of glucokinase investigation.

12. Thus, it acts in a complementary mechanism to GKRP, which also regulates glucokinase protein expression and compartmentation .

13. The researchers hope their findings could enable a therapy to be developed to stop the defective IGRP gene from blocking the glucokinase sensor.

14. The content of liver glycogen and the activity of liver glucokinase were studied.

15. The present invention discloses one new type of low toxicity glucokinase mutant and its preparation process and use.

16. GLP decreases blood sugar, increases insulin secretion, recover the B cells and improve the liver glucokinase activity.

17. Objective To investigate the association between the G/A variant at position-30 of the glucokinase gene promoter in Yunnan Chinese subjects and type 2 diabetes.

18. The diabetic mice induced by alloxan were fed tea polysaccharides for 6 weeks, and observed the changes of the level of blood glucose and the activity of glucokinase in liver.

19. In the same time, the mice's weight decreased and synthesis of glycogen increased, and the activity of glucokinase got improved.