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1 Enter AICAR, which targets a protein called adenosine monophosphate - activated protein kinase ( AMPK ).
2 So, by using AICAR, the scientists thought they might be able to trick the body into thinking it was exercising.
3 When given daily doses of AICAR, but no exercise training, another set of mice could run 23% longer and 44% farther than untreated mice.
4 AICAR, for instance, activates an enzyme that prompts the body to burn fats and sugars when energy levels are low.
5 The scientists examined the effects of two compounds, called GW 1516 and AICAR , on endurance in mice.
6 In a further experiment, the investigators fed untrained mice a substance called AICAR, a synthetic version of AMP that triggers the AMPK switch directly.
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