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1. Its very important to research how to reduce L-asparaginase′s adverse effects. This article summarized the recent research of this respect.
2. The results showed that the matrix can adsorb L-asparaginase and recover high enzymic activity, The immobilize enzyme was more stable against trypsin than native enzyme.
3. L-asparaginase is regarded as an effective anti-cancer drug used for the treatment of acute lymphoblastic leukemia and malignant lymphosarcoma.
4. l-asparaginase is a very effective anti - tumor agent, it is a widely used agent against childhood acute lymphoblastic leukemia (ALL).
5. L-asparaginase(L-ASP) is a very effective therapeutic drug in acute lymphoblastic leukemia for both adult and pediatric patients and included in nearly every ALL protocol.
6. Curing the R plasmids from E. coli J53, the activity of L-asparaginase increased and was close to that of the plasmid free strain.
7. Objective: To investigate the characteristics of adverse drug reaction (ADR) in children caused by L-asparaginase (L-ASP) from clinical practice, and to provide reference for rational use of drugs.
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