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1. In these Patients, reduction of urate excretion reduces stone formation.

2. When allopurinol is utilized to treat severe urate overproduction, xanthine stones may form, but are rare.

3. Such a deposition of urate crystals causes inflammation of the affected area and precipitates an arthritic attack. 206.

4. Result: Saluresis included phosphate, oxalate and urate, et al.

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5. At any rate, the separation ratio is urate.

6. Urate is a salt derived from uric acid.

7. Allopurinol is an appropriate long term urate lowering therapy.

8. Tophaceous gout results from continued precipitation of sodium urate crystals during attacks of acute gout.

9. Genetically obese mice exhibited increased XOR activity and urate in the adipose tissue.

10. Results:Plasmatic urate reduced obviously after treatment, especially after one-week treatment, and accorded with the increase of urate excreted within 24 hours.

11. Advanced gout. Untreated gout may cause deposit of urate crystals to form under the skin in nodules called tophi(TOE-fi).

12. X-rays of affected joints may reveal erosions of bone and punched-out lesions representing urate deposits.

13. These patients typically have mild renal insufficiency and diminished urate excretion due to renal tubular damage.

14. Abnormalities it, urinary but not intestinal excretion of uric acid may produce clinically recognizable disorders of urate metabolism.

15. Hyperuricosuria suggests the presence of uric acid overproduction, while low or normal urate excretion indicates altered renal handling of uric acid.

16. This synovial fluid is then looked at under a microscope and if there is a presence of monosodium urate (MSU) crystals in the fluid than you have gout.

17. The renal biopsy showed features of acute tubular necrosis, deposition of hemosiderin and positive urate stain in the proximal tubular cells, without vascular thrombosis.

18. Methods Gout -relieving effect of GG was observed in rats with adjuvant arthritis induced by sodium urate and in mice with hyperuricemia induced by hypoxanthine.

19. Methods Gout granula was used to treat the acute gouty arthritis in rat urate crystal.

20. The pale areas seen here are tophi, or aggregates of urate crystals surrounded by infiltrates of lymphocytes, macrophages, and foreign body giant cells.

21. Computed tomography may best evaluate bone changes and tophi. Dual energy CT can measure the total urate burden in general periphery joints.

22. This is gout . Gouty arthritis results from deposition of sodium urate crystals in joints.