Similar words: choline, cholinergic, acetylcholine, cholinesterase, succinylcholine, anticholinergic, methacrylate, indomethacin. Meaning: n. parasympathomimetic drug (trademark Mecholyl) that stimulates secretions and smooth muscle activity.
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1. Methods: A 3 year prospective study involving methacholine challenge tests and serially administered questionnaires was undertaken in 769 apprentices exposed to high molecular weight allergens.
2. The methacholine test is considered positive — meaning asthma is present — if the lung function drops by at least 20%.
3. When inhaled, methacholine causes the airways to spasm and narrow if asthma is present.
4. Bronchial responsiveness to methacholine was expressed as a continuous ariable, and analyzed by multiple regression.
5. Cardiac arrhythmias caused by methacholine are particularly prone to occur in patients with hyperthyroidism.
6. During this test, you inhale increasing amounts of methacholine aerosol mist before and after spirometry.
7. Respiratory responsiveness was measured by methacholine chloride bronchial provocation test in 163 new cotton workers before and after 10 weeks exposure to cotton dust.
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8. Methacholine challenge test and measurement of percentage of eosinophils in hypertonic saline-induced sputum were performed before and after the treatment period.
9. A methacholine challenge test will indicate asthma, but it may require the use of a special facility.
10. The mice were then challenged with inhaled methacholine and respiratory system impedance tracked for the following 10 minutes. Respiratory elastance (H) was estimated from each impedance measurement.
11. A bronchodilator (airway-opening drug) is always given at the end of the test to reverse the effects of the methacholine.
12. Methods: Healthy, athletic subjects who are suspected of having exercise-induced bronchospasm were recruited, and FEV1 values were determined following provocative airway challenges with methacholine.
13. Micro-CT images and histograms of Hounsfield units from the lungs also showed increased volume loss in the allergic mice compared with control animals after methacholine challenge.
14. Results: Of the 403 asthmatic children who underwent an MCT, 350 (86.8%) had AHR to methacholine .
15. Results: H was significantly higher in allergic mice than in control animals after methacholine challenge.
16. Sensitized and challenged animals had significantly increased AR to aerosolized methacholine compared with control animals.
17. Objective To investigate the clinical value in the measurement of parameters of the dose response curve (DRC) obtained after the methacholine challenge test.
18. In a separate approach we confirmed the inolement of the lower airways in the response to aerosolized methacholine using tracheotomized mice.
19. Individuals with asthma also have enhanced airway responsiveness to methacholine and diminished airway hydration.
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