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31 However, only for Dipentum did this result in significantly lower 5-ASA mucosal concentrations.

32 Cryptosporidium is a cause of chronic diarrhoea and a proximal small intestinal mucosal enteropathy in children without immune deficiency.

33 Analysis of the anterior wall biopsy specimens showed none of the characteristic histopathological features of mucosal prolapse.

34 Upper gastrointestinal endoscopy and colonoscopy were macroscopically normal and mucosal biopsy specimens were obtained.

35 By contrast there seems to be no increase, or even a decrease, in less serious gastric mucosal injury.

36 These studies show that mucosal metabolism can be assessed effectively using biopsy specimens without the need for epithelial cell purification.

37 It seems possible that this material originates from rare mucosal endocrine cells expressing the gastrin gene.

38 Gastrin is the designation given to a family of protein hormones produced by the mucosal cells of the gastric antrum.

39 Such alkaline secretion may be important in preventing mucosal injury in some patients with gastro-oesophageal reflux disease.

40 Ulcerative colitis and Crohn's disease are chronic, remitting and relapsing mucosal disorders, collectively known as inflammatory bowel disease.

41 The mucosal surface was rinsed with ice cold isotonic saline solution.

42 The study of gastric mucosal proliferation may have important clinical applications.

43 It was beyond the scope of this study to enquire into the way by which urethane inhibits mucosal repair processes.

44 After the intake of azo-bound drugs, the mucosal concentrations are very low despite a low systemic absorption.

45 Therefore we suggest that platelet activating factor should be considered as a global mucosal activity marker.

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46 Models of mucosal damage in which a noxious agent such as ethanol is employed are simply not relevant to chronic duodenal ulcer.

47 Our data are also consistent with observations in man that mucosal proliferation is increased in patients with large adenomas or cancer.

48 In the same biopsy infiltration of the mucosal stroma by a large number of lymphocytes and plasma cells were seen.

49 These results could suggest a prominent role of tissue type plasminogen activator in the pathogenesis of endothelin induced gastric mucosal damage.

50 We found a significant difference in the antral mucosal peptic activity before and after treatment.

51 The dynamics and importance of H pylori reduced altered mucosal peptic activity is far from being clarified.

52 Standard haematoxylin and eosin stained preparations were scored according to the inflammatory scale previously established for use in reservoir mucosal biopsy tissue.

53 Conversely, a low fibre diet did not lead to changes in cellular proliferation which might be associated with mucosal instability.

54 Discussion Our results are consistent with observations in man that mucosal proliferation decreases with distance from the ileocaecal valve to the rectum.

55 Reports of invitro production of cytokines by peripheral or mucosal mononuclear cells in inflammatory bowel disease, however, conflict.

56 Discussion Our present studies implicate active oxygen and lipid peroxidation in the pathogenesis of gastric mucosal injury induced by indomethacin.

57 These results give rise to the hypothesis that endothelin might increase the tissue type plasminogen activator activity accompanying the gastric mucosal injury.

58 Limited studies have been published on human gastric mucosal cell proliferation and a detailed overview of such work has been published.

59 Hence, we postulated that adaptive cytoprotection maintains a physiological equilibrium between duodenal mucosal resistance and luminal acidity.

60 Platelet activating factor causes gastrointestinal mucosal injury and ischemic bowel necrosis.