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1 OBJECTIVE:Improve the synthetic method of diphenoxylate hydrochloride, which was more suitable for the industrial process.
2 Objective:To understand the situation of compound diphenoxylate tablets abuse in Kunming.
3 A rapid method for the simultaneous determination of diphenoxylate and atropine by capillary electrophoresis with high frequency conductivity detection was described.
4 METHODS:Mouse model of constipation was established by compound diphenoxylate, and rat model hyperlipemia was established by high fat forage.
5 Methods It was taken orally with Asi antidiarrheal capsule in treatment group and taken orally with Diphenoxylate in control group.
6 HPLC method for the determination of atropine sulfate in compound diphenoxylate tablets was established.
7 A HPLC method for the determination of atropine sulfate in compound diphenoxylate tablets was established.
8 Adverse reaction of otilonium bromide was few, but colloidal bismuth and diphenoxylate can cause the constipation after using for a long time.
9 Method:32 cases were treated with Repleshing Spleen to Stop Diarrhea Decoction as the study group while 30 cases were treated with Vit B1, Compond Diphenoxylate and Berberine as the control group.
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