Similar words: neurotoxin, enterotoxin, exotoxin, mycotoxin, cytotoxin, endotoxin, immunotoxin, tetrodotoxin.
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1. The active ingredient of Coccolus indica is picrotoxin. It is a neurotoxin. Do not over dose.
2. It was found that the antagonist picrotoxin was unable to block the liver fluke to the excitatory effect of GABA, while it could partially block the roundworm to the inhibitory effect of GABA.
3. Objective To observe the kindling model of Sprague Dawley (SD) rats induced by injection of different doses of picrotoxin (PTX) intraperitoneally, and to evaluate the effect of the drug on the model.
4. In midbrain slices from rats treated with saline or a single dose of cocaine, LTP could not be induced in VTA dopamine neurons unless GABA-mediated inhibition was reduced by bicuculline or picrotoxin.
5. But yohimbine could not antagonize the central hypotensive action of GABA, while picrotoxin could entirely block it.
6. Conclusion: Melatonin does not exhibit its potentiation sleeping time in mice through melatonin 3 receptor. Hypnotic activity of melatonin may be mediated through picrotoxin site on GABAA receptor.
7. This drug also displayed some antagonisms for pentobarbital sodium and ketamine, and increased actions of picrotoxin.
More similar words: neurotoxin, enterotoxin, exotoxin, mycotoxin, cytotoxin, endotoxin, immunotoxin, tetrodotoxin, thyrotoxic, neurotoxic, nephrotoxic, thyrotoxicosis, microtomy, microtome, toxin, ototoxic, antitoxin, aflatoxin, saxitoxin, ciguatoxin, tetanus antitoxin, endotoxic, cytotoxic, phytotoxic, cardiotoxic, hepatotoxic, cytotoxicity, cytotoxic drug, protoxylem, cytotoxic t cell.