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1. Jak, 45, of Middleton-St-George, Darlington, bought his runabout machine for a couple of hundred pounds.

2. Conclusion: Our study indicates that JAK kinase can affect the activity of ERK signal transduction pathway through the phosphorylation of ERK.

3. The inhibitory effects of JAK kinase on MMP-9 expression and invasion of breast cancer cells are associated with the blocking of the ERK signaling pathway.

4. SOCS3 is a suppressor of JAK/STAT signal transduction pathway and indirectly regulates STAT3 phosphorylation, which associates closely with the occurrence of cancer.

5. The JAK/STAT pathway that contributes to signal transduction by cytokines, growth factors and hormones is universally activated in leukemias.

6. Two important cell signal pathways, JAK -STAT pathway and MAPK pathway, transfer the signals between regulators and hematopoietic relative genes.

7. Although IFNs activate JAK -STAT pathway, several studies suggest that there may be some alternative regulatory mechanisms of IFN signaling.

8. Re-read entries, as people do not feel jak class has always maintained that, as is the Wan Ku children, the embodiment of evil.

9. Conclusion As an inhibitor of JAK, AG 490 can influence the function of normal cells.

10. Brown country rice, curried lentils, Jak fruit - the lunch is hearty and generous but I cannot eat.

11. Another form of action game are the platform games like Jak and Daxter, Crash Bandicoot and Rayman 2.

12. In BCR - fusion gene negative myeloproliferative diseases, the discovery of JAK 2 V 617 F point mutation is an important landmark.

13. After being met at the airport by a driver and shuttled to my new accommodations, a member of the JAK production team met up with me.

14. The present invention relates to compounds of formula (I) useful as inhibitors of protein kinases, particularly of JAK family kinases.

14. Sentencedict.com try its best to gather and create good sentences.

15. We incidentally found that STAT1C overexpression cause aberrant STAT activation in LL2 cells. Further studies on the underlying mechanisms may explore a novel regulatory system of JAK/STAT pathway.

16. Over 50% of human cancers have been identified as resulting from just two intracellular signaling pathways: the JAK/STAT and p53/ras pathways.

17. STAT proteins are activated by G-protein coupled receptors, while it has not been reported whether CCK receptors, a kind of G-protein coupled receptors, can activate JAK/STAT pathway.

18. In our preliminary experiment, the natural product calycosin has been observed to activate JAK/STAT pathway.