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1 Cucurbitacin B is mainly used to treat hepatitis and liver cancer in clinic.

2 Objective To study the distribution of cucurbitacin B loaded PLGA nanospheres in mice.

3 Methods The solid lipid nanoparticles(SLN) containing cucurbitacin B were prepared by high-pressure homogenization method.

4 Photodegradation of cucurbitacin E conformed to first-order degradation kinetics under various conditions. The photolysis kinetics of cucurbitacin E solution was different at different concentrations.

5 Conclusions Cucurbitacin E is insoluble in water,(www.Sentencedict.com) its partition coefficients for n-octanol-water and liposome-water are moderate.

6 In addition the stability of cucurbitacin B was studied in this paper.

7 With the cucurbitacin, cucumber, such as acid can help the lung, stomach, liver detoxification.

8 Conclusion: Cucurbitacin B has the protective effects on the liver injury induced by CCL4.

9 Moreover, a freeze-drying method was investigated in order to improve the stability of the cucurbitacin SLN suspension.

10 An HPLC method was developed for the assay of cucurbitacin B in drug and preparation.

11 Determination of drug solubility in water and adjuvants showed cucurbitacin B was insoluble in water and relatively more soluble in various oil, emulsifier and co-emulsifier.

12 Results of the stability experiments indicated that the physical and chemical stability of cucurbitacin B microemulsion was much more improved after freeze-dried.

13 Objective To establish an RP-HPLC method for the determination of cucurbitacin B laurate in nanoemulsions.

14 According to the results of the study before formulation designing, emulsification-ultrasonic method was developed to prepare cucurbitacin SLN suspension, with stearic acid glyceride as lipid carrier.